Depressive disorder is a multidimensional medical condition reaching many therapeutic desiderates, including negative mood, psychotic elements, anxiety and a low quality of life. Understanding this condition and recognizing its manifestations are vital for a depressive patient in order for him to achieve a better therapeutic management. Unfavourable development of the disorder is significantly associated with social malfunction, severe deterioration of interpersonal relationships, low treatment adherence and reduced life quality. On the other hand, a good insight may improve patient’s adherence and mental hygiene. There is little information regarding the patient’s life quality insight and adherence to treatment. Purpose: We intend to investigate whether there is a significant correlation between patient’s insight of his health and life quality and the adherence to treatment. Material and methods: We investigated a group of 38 patients with depressive disorder, treated with Quetiapine 200 – 400 mg/day, aged between 18 and 80, having no other ma-jor comorbidity. We used the SF36 life quality test and the TAT treatment adherence the-rapy. The SF36 was filled by both the patient and his attending psychiatrist who also considered the patient’s medical, familial and social context. From these SF36 tests, results a discrepancy which is the expression of the difference between the patient’s subjective self views and his real status. This is an inverted measure of the insight, which we correlated with the adherence score. For statistics, we used SPSS.17. Results and discussions: The Simple Scatter diagram showed a negative linear relation between the SF36 discrepancy and the adherence, meaning that low discrepancy is associated with high adherence. This correlation is significant at a high level p < 0,01 (2-tailed). The correlation coefficient is r = -0,772, meaning that there is a significant negative correlation between the SP36 discrepancy and the adherence. We have also made a regression test in order to outdraw the prediction value of the discrepancy. Since the SP36 discrepancy expresses the quality of the insight, we may draw the conclusion that the more adequate the patient’s insight, the more adherent he will be to treatment. The clinical relevance of the study is related to the fact that insight and adherence are in a biangular relation, forming a vicious circle of dissatisfaction and treatment abandon. On the other hand, improving the patient’s insight towards his life quality by empathic information and case assessment would probably improve his adherence to treatment. Conclusions: Major depression is associated with inadequate insight of patient’s life quality that is disruptive from reality (the patient believes that his life quality is much worse then it really is). The level of this inadequacy is significantly correlated with patient’s adherence to treatment. The insight is a partially correctable factor that may lead to a better adherence.