Perceived as an itching, ranging in intensity from one person to another, pruritus is a frequent symptoms of dermatological diseases. Pruritus may be considered a functional disorder in which the psychogenic factors play an important role in its onset. Skin diseases are significantly conditioned by stress and emotions, those influences on the skin beeing mediated by the nervous system including the autonomic, immune or hormonal system. The diagnosis of psychogenic pruritus is determined after eliminating any other causes of pruritus, so it is a diagnosis of exclusion. The quality of life to a patient with psychogenic pruritus in influenced in a negative way just because of the impact created by its awareness of his skin symptoms, expressed by itching, scratching lesions, sometimes quite severe marks. There is no specific treatment in such situations. The optimal treatment is the etiologic one, by eliminating as much as possible the triggering factors/condition.