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ISSN 2393 – 2694

ISSN–L 1453 – 7257

Frequency: 4 issues/year

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Depuneti prin mandat postal suma de 100 RON reprezentand contravaloarea abonamentului pe un an la Buletin de Psihiatrie Integrativa, pe adresa: D- lui Dr. IOAN MIHALACHE Institutul DE PSIHIATRIE "SOCOLA" (Clinica II F) SOSEAUA BUCIUM, NR. 36, 700282, IASI

TREATMENT OF WITHDRAWAL SYNDROME (DELIRIUM TREMENS). CLINICAL TRIAL


Autori: DINU Elena

Cuvinte cheie: treatment, effectiveness, benzodiazepines, Tiapridal, side effects, tolerance

Abstract:

The alcoholic withdrawal is associated with a significant morbidity and mortality when improperly managed. All patients need general support; a certain percentage of them need a pharmacology that changes the evolution of the inversion of the neural adaptation induced by alcohol. Benzodiazepines are acknowledged as the elected treatment of alcohol withdrawal. They are cross tolerant with the alcohol and possess anticonvulsant properties. There still are a number of patients for whom the treatment with benzodiazepines is not appropriate due to their side effects. This is why the object of this study is the treatment of delirium tremens with benzodiazepines versus the treatment with Tiapridal (free of the side effects of benzodiazepines). The method used comprises the study of 100 patients suffering from delirium tremens who were treated as follows: 50 patients with Tiapridal and 50 patients with Diazepam. They were monitored 7 days. Results: The Tiapridal is more effective in its action of sedation regarding the other analyzed items. There are no significant differences from the statistic point of view (this may also be due to the small number of patients in the study). To conclude, the side effects are the ones that recommend the treatment with Tiapridal on certain categories of patients: patients with respiratory depression, patients with a hepatic disorder, patients who are benzodiazepine dependent, patients with nausea and vomiting.

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