The Irritable Bowel Syndrome (IBS) is one of the most frequent commorbidities of the depressions, unfortunately insufficiently known and therefore rarely diagnosed in our country. This is due firstly to underevaluation of the IBS aspects, in the context of psychiatric phenomenology and secondly to psychiatrists’ attitude and inclination to „psycologize” any phenomenon related to digestive dysfunctions area and last but not least, we have to honestly accept, due to ignorance of the symptomatology of this syndrome which is encoded in ICD-10 at K58. After a presentation of the incidence of IBS among the depressive in-patients at „Socola” Neuropsychiatric Hospital in Iasi (Romania), the authors review the physiopathologic, diagnostic and therapeutic particularities of this commorbidity.