Background The high prevalence of alcoholism-depression comorbidity raises diagnostic difficulties that affects therapeutic assistance and the development of cases. An appropriate treatment assistance, with the obtaining of the remission of the psychotic symptoms, should reduce the number of comorbid cases and provide a development and a favourable prognosis with fewer recurrences. Objectives Setting the prevalence of recurrence in patients with depressive comorbidity. Method Our study is a descriptive one and it included a group of 158 patients, who came for the first time in the hospital for alcohol-related disorder and had depressive symptoms and they have been monitored over a period of four years. Results About 70% of the patients experienced at least one alcoholic and depressive relapse, while at only 11% complete remission was found after the first hospitalization. Conclusions The difficulty of the alcoholism treatment is underlined by the fact that alcohol becomes the therapeutic agent associated to the consequences that it has upon the candidates to addiction. As long as the individual sees the alcohol as the remedy to his emotional problems, he will become psychologically dependent and return to the habit of drinking, even after repeated attempts of abstinence, thus falling in relapse.