Menopause or climax is a physiological condition that women go through around the age of 50, and that corresponds with the definitive stop of the menstrual cycle, due to the exhaustion of the ovarian function. Menopause can be normal or pathological, in proportion to the age when it occurs and to the average or significant intensity of the chemical phenomena accompanying it, as it signals the woman’s transition from a biological stage, through climacterium, to senescence (old age). Against this background of significant decrease of the estrogens, a series of various psychic disorders can appear, ranging from hyperemotivity, irritability, whims, susceptibility, to anxiety, phobias, pessimism, or even dementia. The low catecolaminic activity of the brain is part of the psychic depressions that occur during menopause. The estrogen deficiency can create problems for the sexual activity during menopause through the appearance of trophic disorders at the vaginal level, which can lead to the manifestation of dyspareunia (painful sexual intercourse). The sexual behaviour is modified either by the decrease of the libido and frigidity, or, in a small number of cases, by its significant increase, accompanied with jealousy and passional attitude. Estrogens are and remain a logical and efficient therapeutic solution for menopause disorders, regardless of the affected tissues. The substitutive treatment has a protective action, leading to an increase of the life satisfaction in parallel with the process of population aging.