Background: The impact of raising a child with autism on parents' quality of life (QOL) is not yet fully understood. QOL is influenced by different factors. Objectives: To evaluate the QOL of the families of children with autism compared with that of families of children diagnosed with ADHD. Method: We used data from 35 children, aged between 2 and 18 years, diagnosed with ASD or ADHD and their parents. For assessment we used specific, standardized instruments. Results: The areas with the lowest scores in terms of FQOL were the financial status, the support from others and the support from services. Conclusion: By understanding how the FQOL is affected by these disorders, the needs of the children with developmental disorders and their families will be better recognized and healthcare and support services would be appropriately developed.