The modern literature considers that although it is not possible to reproduce in animals all autistic symptoms, as for example the deficiencies of language or intuitive ability, most animal models of autism developed so far are able to shape a series of typical symptoms through certain tasks that assess mostly the sociability, vocalization or the change of routine. In this way, all teratogenic agents who can induce this complex disorder are acting during the first eight weeks after conception. While this is a very important aspect in the generation of potential animal models of autism, it also represents an evidence that autism arises very early in development of the individual. We present here the relevance of an increase valproic acid administration in the generation of an animal model of autism, as well as the cognitive deficits generated in this model, as tested through some specific behavioural tasks for memory assessing.