Objective: Recurrent depressive disorders are the most prevalent psychiatric disorders worldwide and in consequences this fact raise several major problems related to public state of health. Our main goal was to establish a clinical and socio-demographic profile of patients with recurrent depression admitted in our Clinic. Material and method: We conducted a retrospective study on 136 patients admitted in our Clinic during 2001-2003 with diagnostic of recurrent depressive disorders according with ICD-10 criteria. The results were statistical analyzed. Results: Recurrent depression was more prevalent in females than in males, males developed more sever clinical forms than females including psychotic features. Professional status was significant impaired by depression while marital status didn’t indicate important changes. Psychotic depression was present just in almost one third of all depressive patients. Personality has had just a limited and guiding role to predict severity of depression. Somatic comorbidities were very important both at the onset but especially after several years of depression. Conclusion: Some data resulted from our study confirm data from international literature. Depression has a differential impact on subjects with depression, professional status being the most impaired due to academic disabilities related to depressive disorders. The suicidal risk was direct correlated with instructive level and with severity of depression. The high prevalence of somatic comorbidities could indicate both the effectcausal relation between depression and some somatic illnesses or the two different fenotypical aspects of the same genotype. Finally both pathological conditions require equal attention by clinicians.