Introduction. Personality disorders are very often associated with comorbide conditions that affect the adaptive deficit. Study objective was to highlight the role of social and family factors in the prognosis of patients with personality disorders that associate or not comorbide disorders. Material and methods. It is a prospective, observational study in which were included all patients hospitalized in Psychiatry Clinic II Târgu Mures during 2009 – 2010, who meet the criteria for inclusion in the study. It was applied the test SCIDII – questionnaire and test, Hamilton depression scale, Hamilton anxiety scale at the time of hospital admission, at discharge, after 3 months, 6 months, 9 months, 12 months, 18 months and 24 months. Patients were divided into three groups according to the association or not of affective episodes with personality disorder. Parameters were followed as family status, occupation, personal history, family history and evolution in dynamic roles in the course of 24 months.