Psychodermatology covers all aspects of how the mind and body interact in relation to the onset and progression of various skin disorders. Unlike most internal illnesses, skin disease is often immediately visible to others, and therefore people suffering from dermatological conditions may suffer social and emotional consequences. Skin is an organ that has a primary function in tactile receptivity and reacts directly upon emotional stimuli. Dermatological practice involves a psychosomatic dimension. This review intends to present the relationship between the ‘skin’ and the ‘mind’ specifically from the dermatology point of view, with focus on bacterial skin infections. The effects on the quality of life as a result of psychodermatological conditions are highlighted. A multidisciplinary approach for treatment from both dermatologic and psychiatric viewpoints is very important.