Millions of women of reproductive age have recurrent emotional, cognitive, and physical
symptoms related to their menstrual cycles. These symptoms often recur discretely during the lutheal
phase of the menstrual cycle and may significantly interfere with social, occupational, and sexual
functioning. Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome
(PMS). Current research implicates mechanisms of serotonin as relevant to ethiology and treatment.
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