Background and Aims: In 2007, Romanian Health Ministry implemented in pilot phase a national program, designed to pay smoking cessation experts and to reimburse cost of three types of pharmacological therapies for nicotine dependence induced by tobacco smoking. The aim of the study was to evaluate the impact of the first totally reimbursed smoking cessation program run in our center, to debate the role of reimbursement on success rate of quitting tobacco use and to identify the gaps and the values of the pro-gram, based on a first 3 months expertise. Material and methods: Patients were sent by G.P.-s, or addressed by media to the smoking cessation center in October ? December 2007, in a first phase of the pilot program de-signed to cover expenses for three months pharmacological treatment and counselling for nicotine dependent smokers. The patients received one initial evaluation visit, two fol-low-up visits and a final visit. The smoking abstinence was assessed by the carbon monox-ide measurement in exhaled air and by urinary cotinine tests. Results: Among 100 initial consults appointed, 46 subjects were found eligible to receive nicotine dependence therapy. The treatment was completed by 54.3 % of the subjects, with 8.7* lost in follow-up and 15.2 % side-effects requesting to abandon the therapy. Overall success rate was 34.7 %, higher than prior 28 % established in our center before this program. Conclusions: Tobacco smoking is defined as a chronic relapsing disease which determines dependence to nicotine, a drug contained in any tobacco product Reimbursement of ther-apy for nicotine dependence and providing qualified personnel for smoking cessation activity has increased patients ‘compliance to quitting tobacco use.