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ISSN 2393 – 2694

ISSN–L 1453 – 7257

Frequency: 4 issues/year

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Depuneti prin mandat postal suma de 100 RON reprezentand contravaloarea abonamentului pe un an la Buletin de Psihiatrie Integrativa, pe adresa: D- lui Dr. IOAN MIHALACHE Institutul DE PSIHIATRIE "SOCOLA" (Clinica II F) SOSEAUA BUCIUM, NR. 36, 700282, IASI

THE RELATIONS BETWEEN ANGIOTENSIN-II INDUCED HYPERTENSION AND ANXIETY IN RATS. THE RELEVANCE OF OXIDATIVE / NITROSATIVE STRESS


Autori: .Selectati autorul, CIOBÎCA Alin, BILD Walter, DOBRIN Romeo, PETRARIU Florin, COJOCARU Dumitru

Cuvinte cheie: anxiety, hypertension, oxidative stress, nitrosative stress

Abstract:

Lately, a large number of studies have displayed an increased interest regarding the connections and interactions that might appear between hypertension and anxiety, with conflicting results reported about these aspects. Also, it has been suggested that both oxidative and nitrosative stress might regulate the connections between anxiety and hypertension. In this way, in this paper, we were interested to see the relevance of oxidative/nitrosative stress in the connection between angiotensin-II induced hypertension and anxiety behaviour in rats, by determining the connection between the results of elevated plus maze behavioural test and some oxidative / nitrosative markers. We found a significant correlation between the level of anxiety, expressed as the time spent in the open arms of the elevated plus maze and the oxidative stress markers which resulted after angiotensin II administration. This study could results in opening new avenues for research into the causal role of both oxidative and nitrosative stress in anxiety and hypertension. These results might be of great importance in understanding the connections between the hypertension and anxiety process, as well as in establishing.

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