Considering the fact that human being is a biopsychosocial entity, irrespective of nature or action’s mode of any external factor either noxious, aggressive or beneficial, the individual and his organism react as a whole at all his levels: physical, physiological, neLiroendocrinological, psychological, behavioural, social. The appearance of some mood disorders in connection (more or less direct) with some endocrine modifications (puberty, menstruation, pregnancy, breastleeding menopause, hyperthyroidism, corticoid therapy, ACTH, anticonceptive drugs, etc.) shows a favourable and even a triggering role that all the hormonal factors are playing it in mood disorders. In the appearance of the depressive syndrome, we can speak of multiple factors/conditions who have an influence on the human psychic. These stress-inducing” factors can be of physical, chemical(etc.) nature and can affect the mental state, either directly, through an action on some neurohumoral mechanisms, on the central nervous system and superior nervous activity (the anatom—functional substrate of psychical activity), or indirectly, as a psychical stress (when the individLial perceives the professional factors as an obstacle, difficulty or a threat). It is known that almost all endocrine systems are regulated by our cortex and as such these systems will have some anomalies in mood disorders.