In the recent decades, there was a rapid increase of depression among population, including its refractory variants, and researches show that in resistant depression predisposing causes are distinguished by a pronounced degree of expression [3, 7, 8, 16]. It is necessary that the research methods to be limited to the decisive ones, as well as establishing the correct amount of treatment, based on continuity of therapy, which effectively reduces the terms of hospitalization and financial costs [1, 4, 6, 10, 11]. The clinical analysis of patients suffering from refractory depression, admitted in Psychiatric Clinic, Chisinau, revealed psychopathological pathomorphosis, which included delusions of guilt, incurable somatic disease, accusatory hallucinations, suicidal attempts, as well as disturbance of depressive syndrome components with development of monotonous, rigid affect. The most characteristic variants for resistant depression are anxiety, melancholy, apathy and inhabitation. The complex therapy that included antidepressants, timostabilizators, sometimes, electroconvulsive therapy proved to be effective in overcoming the acute states and establishing remission. Treatment with antidepressants was initiated in moderate doses, but augmentation was relatively rapid, avoiding polypragmasy. Psychotherapy, originally applied to explain the goal, therapeutic tactics, nature of disease, peculiarities of development, duration of treatment, proved to be one of the basic methods of numerous therapeutic interventions.