Background Chronic obstructive pulmonary disease – COPD is a common chronic lung disease that has a significant impact on the quality of life of those with the condition. It impacts on patients’ lives through restriction of activities, interference with sleep and limitation of social life. These patients are not only limited in their activities due to respiratory disease, but also have depressive symptoms caused by main disability and also the glucocorticoid-based drugs administered. Objective The purpose of this work is to investigate the depressive symptoms – with the help of a psychologist – on patients participating in a clinical trial for asthma/COPD natural medication. Method We selected 62 patients out of our 128 pool, all under glucocorticoid medication, and conducted a psychological interview using the HAM-D17 scale for reporting the results. Results After calculating the scores, we found out that 43% of our patients experienced depressive symptoms.