This study assesses the therapeutic efficiency of the antidepressant Venlafaxinum in the complex treatment of affective disorders in alcoholics suffering from repetitive alcoholic psychosis. Concluded in 2010, the one–year study of groups of 112 patients, men 25 – 55 years of age diagnosed with chronic alcoholism of 5 – 15 years, who were treated in the Psychiatric Clinical Hospital of Chisinau. The study showed the efficiency of Venlafaxinum in the treatment of affective disorders in alcoholic patients given the daily dose of 75 – 150 mg, taken for periods up to two months. It can be recommended as a first- choice medication in diminishing pathological alcoholic addiction throughout the period of therapeutic remission.