Ekbom syndrome, popularly known as delusional parasitosis, at first sight, is not a severe disease, without endangering the patient’s life, yet it is disabling for the individual in terms of quality of life. We present two cases of patients diagnosed with Ekbom syndrome. Both of them had a special social status, being itself isolated from the rest of the family, in fear of transmitting the disease to them. Presumptive diagnosis of the disease is determined by the dermatologist, later confirmed by the psychiatrist who remains responsible for the treatment of this disease with significant impact on the patient’s life. Addressability to a psychiatrist manifested by patients with Ekbom syndrome is reduced due to the difficulty of accepting that the skin lesions do not require dermatologic treatment, but psychiatric evaluation and supervision. Up to the correct diagnosis and treatment, these patients’ quality of life is deeply affected.