Corticosteroids are widely used anti-inflammatory and immunosuppressive pharmacological agents in various pathologies, such as asthma, allergies, rheumatologic or dermatologic conditions, etc. Their incontestable efficiency comes with a price: their multisystemic side effects, such as failure to thrive in children, hypertension, hyperglycaemia, osteoporosis, metabolic disorder, glaucoma, cataract and not least – but often neglected or under-diagnosed – mental disorders. Among the last, it is worth mentioning depression, mania, catatonia, cognitive impairment, behavioural disorders, ideation and suicide attempts. It is fundamental to detect them, considering their potential devastating effects on the patients’ functionality and integrity, and in order to find an adequate therapeutic approach, by decreasing the corticosteroid dosages considering the general state of the individual and by choosing proper psychotropic agents.